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51.
T Nohara M Iwamoto K Sumiyoshi S Tanaka K Kimura Y Takahashi N Tanigawa 《Oncology letters》2010,1(4):669-672
This study examined the therapeutic efficacy of TS-1 in the treatment of locally recurrent breast cancer. Between August 2006 and May 2009, 7 patients with local breast cancer recurrences were selected included in the study. The sites of recurrence were the cervical lymph nodes in 4 patients, the axillary lymph nodes in 2 and the thoracic wall in 1. Among the 7 patients, 6 were administered TS-1 as first-line treatment and 1 was administered TS-1 as second-line treatment. Complete response (CR) was achieved in 2 patients, 1 achieved partial response, 2 had stable disease (SD), 1 had long SD and 1 had progressive disease. The overall response rate was 43%, and the clinical benefit rate was 57%. A patient with recurrence of breast cancer in the thoracic wall 28 years after surgery also achieved CR following therapy. The only adverse event observed was a case of hand-foot syndrome in 1 patient. No patients withdrew from treatment, and favorable compliance was achieved in the study. The results indicated that TS-1 has the potential to be one of the drugs for first-line treatment of locally recurrent breast cancer. 相似文献
52.
Horiuchi Y Iida S Koga M Ishiguro H Iijima Y Inada T Watanabe Y Someya T Ujike H Iwata N Ozaki N Kunugi H Tochigi M Itokawa M Arai M Niizato K Iritani S Kakita A Takahashi H Nawa H Arinami T 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2012,(1):30-37
Glutamate is one of the key molecules involved in signal transduction in the brain, and dysfunction of glutamate signaling could be linked to schizophrenia. The SLC1A1 gene located at 9p24 encodes the glutamate transporter EAAT3/EAAC1. To investigate the association between the SLC1A1 gene and schizophrenia in the Japanese population, we genotyped 19 tagging single nucleotide polymorphisms (tagSNPs) in the SLC1A1 gene in 576 unrelated individuals with schizophrenia and 576 control subjects followed by replication in an independent case-control study of 1,344 individuals with schizophrenia and 1,344 control subjects. In addition, we determined the boundaries of the copy number variation (CNV) region in the first intron (Database of Genomic Variants, chr9:4516796-4520549) and directly genotyped the CNV because of significant deviation from the Hardy-Weinberg equilibrium. The CNV was not associated with schizophrenia. Four SNPs showed a possible association with schizophrenia in the screening subjects and the associations were replicated in the same direction (nominal allelic P?0.05), and, among them, an association with rs7022369 was replicated even after Bonferroni correction (allelic nominal P?=?5?×?10(-5) , allelic corrected P?=?2.5?×?10(-4) , allelic odds ratio, 1.30; 95% CI: 1.14-1.47 in the combined subjects). Expression analysis quantified by the real-time quantitative polymerase chain reaction in the postmortem prefrontal cortex of 43 Japanese individuals with schizophrenia and 11 Japanese control subjects revealed increased SLC1A1 expression levels in individuals homozygous for the rs7022369 risk allele (P?=?0.003). Our findings suggest the involvement of SLC1A1 in the pathogenesis of schizophrenia. 相似文献
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54.
Shigeharu Inouye Atsushi Tamura Tetsutaro Niizato Tomio Takeuchi Masa Hamada Shinichi Kondo 《Journal of infection and chemotherapy》1996,2(2):84-89
The antibacterial activity of 2″-amino-2″-deoxyarbekacin (AmABK) and 2″-amino-5,2″-dideoxy-5-epiaminoarbekacin (Am2ABK) was comparable to, or slightly less than, that of arbekacin (ABK) against gram-positive and gram-negative bacteria, including
60 stock cultures and 50 clinical isolates ofPseudomonas aeruginosa, but more potent against 31 isolates of MRSA possessing an aminoglycoside-modifying enzyme APH(2″)/AAC(6'). AmABK and Am2ABK showed in vivo activity which paralleled in vitro MICs, and were less toxic than ABK in acute toxicity in mice and nephrotoxicity
in rats. These results indicate that the 2″-amino group introduced to ABK confers high stabilization to the aminoglycoside-modifying
enzymes, while reducing acute and renal toxicities. 相似文献
55.
M Yokota T Niizato S Inouye I Kitasato 《Drugs under experimental and clinical research》1989,15(6-7):261-272
Intramuscular administration of glucarolactam in the form of aminoglycoside salt to guinea-pigs protected the experimental ototoxicity caused by high dosing of aminoglycoside antibiotics. The protection was evidenced by the pinna reflex threshold and histochemical examinations of hair cells of cochlea as well as body weight gain. The degree of protection differed with the aminoglycosides, and high protection was observed for dibekacin, gentamicin, tobramycin, followed by kanamycin and bekanamycin. However, protection was weak or not observed when glucarolactam was administered as a mixture of glucarolactam potassium and aminoglycoside sulfate. Serum analysis of the guinea-pigs on day 14 post-administration as a measure of nephrotoxicity revealed that glucarolactam suppressed the elevation of BUN and serum creatinine caused by the aminoglycosides. The protective effect of glucarolactam on the aminoglycoside-induced nephrotoxicity in the dehydrated rats did not differ between the salt and the mixture. No difference in the in vivo antibiotic activity against bacterial infections of mice was observed between the salt and the mixture. 相似文献
56.
Arai T Uéda K Ikeda K Akiyama H Haga C Kondo H Kuroki N Niizato K Iritani S Tsuchiya K 《Neuroscience letters》1999,259(2):83-86
Argyrophilic glial inclusions occur in the midbrain of patients with Parkinson's disease (PD) and diffuse Lewy body disease (DLBD). These inclusions are immunohistochemically positive for NACP/alpha-synuclein but negative for tau protein. The results of the present study suggest that a primary degenerative process involves NACP/alpha-synuclein in PD and DLBD and that the process takes place not only in neurons but also in glial cells. Argyrophilic cytoplasmic inclusions, both glial and neuronal, in a variety of degenerative diseases may be grouped into two major categories; one related to aggregates of abnormally phosphorylated tau protein and the other to unusual accumulations of NACP/alpha-synuclein. 相似文献
57.
Yasue Horiuchi Makoto Arai Kazuhiro Niizato Shyuji Iritani Emiko Noguchi Tsuyuka Ohtsuki Minori Koga Tadafumi Kato Masanari Itokawa Tadao Arinami 《Neuropsychopharmacology》2006,59(5):434-439
BACKGROUND: Results of recent DNA microarray analyses of postmortem brains of patients with schizophrenia revealed that expression of the PDZ and LIM domain 5 gene (PDLIM5) is increased. In the present study, we examined whether polymorphisms in PDLIM5 are associated with schizophrenia. METHODS: We screened for mutations in PDLIM5 in 24 Japanese patients with schizophrenia and evaluated the associations of the identified polymorphisms with schizophrenia in a Japanese case-control population (total samples, 278 schizophrenia patients and 462 control subjects). Expression of PDLIM5 was quantified by real-time quantitative polymerase chain reaction (PCR) in postmortem prefrontal cortex of 34 schizophrenia patients. Electrophoretic mobility shift assay (EMSA) was performed to examine whether a polymorphism influences nuclear protein binding. RESULTS: We identified 27 polymorphisms in PDLIM5 and found associations between polymorphisms (rs2433320 and rs2433322) in the 5' region of the gene and schizophrenia (p = .004). Real-time quantitative PCR revealed that these polymorphisms influenced gene expression (p = .007). An EMSA showed that the different alleles of the rs2433320 polymorphism bound differently to nuclear proteins. CONCLUSIONS: These results suggest that PDLIM5 might play a role in genetic susceptibility to schizophrenia. 相似文献
58.
Tsuchiya K Nakayama H Haga C Oshima K Niizato K Arai T Matsushita M Akiyama H 《Acta neuropathologica》2005,110(1):57-68
We investigated clinicopathologically four Japanese autopsy cases of diffuse neurofibrillary tangles with calcification (DNTC), which has been believed to be characterized by temporal or temporofrontal circumscribed lobar atrophy, and examined the distribution of their cerebral cortical lesions using hemisphere specimens. The lesions were classified into three categories (slight, moderate, and severe). Severe lesions were present in the temporal lobes and insular gyri of all four cases, consistent with the studies reported to date. In contrast, severe lesions were encountered in the parietal lobe of case 1 and moderate lesions were found in the parietal lobes of cases 2–4. Furthermore, moderate lesions of the precentral gyrus were present in cases 2–4, and moderate lesions of the postcentral gyrus were encountered in all four cases. We postulate that the distribution of cerebral cortical lesions in DNTC is more widespread than previously assumed. Our data also indicate that the unusual clinical signs of DNTC reported by several Japanese researchers, including parietal signs such as apraxia and agnosia, are roughly consistent with the topographic distribution of cerebral cortical lesions in DNTC elucidated in this study. 相似文献
59.
Tsuchiya K Ikeda K Mimura M Takahashi M Miyazaki H Anno M Shiotsu H Akabane H Niizato K Uchihara T Tominaga I Nakano I 《Acta neuropathologica》2002,104(3):249-259
We investigated clinicopathologically pyramidal signs, including hyperreflexia, Babinski sign, and spasticity, and the involvement of the primary motor cortex and pyramidal tract, in eight Japanese autopsy cases of amyotrophic lateral sclerosis (ALS) with dementia. Pyramidal signs were observed in seven (88%) of the eight autopsy cases. Hyperreflexia and Babinski sign were evident in seven (88%) and three (38%) patients, respectively, but spasticity was not observed in any of the eight patients. Loss of Betz cells in the primary motor cortex was evident in the seven cases in which this structure was examined. Astrocytosis in the fifth layer of the primary motor cortex was noticed in three cases. In all eight cases, involvement of the pyramidal tract was obvious in the medulla oblongata, but no involvement of the pyramidal tract was found in the midbrain. Involvement of the pyramidal tract in the spinal cord, particularly of large myelinated fibers, was observed in all six cases in which the spinal cord was examined. In ALS with dementia, pyramidal signs were shown to be present more frequently than previously believed, and the clinicopathological correlation between pyramidal signs and involvement of the pyramidal tract was obvious. Constant involvement of Betz cells and the pyramidal tract in ALS with dementia has not been reported. Our clinicopathological findings may make a contribution to the understanding of the clinicopathological hallmarks of this disorder. Furthermore, we believe that this study will also contribute to the elucidation of the nosological status of ALS with dementia. 相似文献
60.
K. Ikeda Haruhiko Akiyama Shuji Iritani Kase. Koichi Tetsuaki Arai Kazuhiro Niizato Noriomi Kuroki Kenji Kosaka 《Acta neuropathologica》1996,92(5):534-539
A 57-year-old woman showed progressive sensory aphasia as an initial symptom, and then developed total aphasia within 6 years
and, finally, severe dementia. Neuropathologically, the cerebral cortex was most severely affected in the superior and transverse
temporal gyri, and subsequently in the inferior frontal gyrus, especially in the pars opercularis. The degeneration in the
subcortical grey matter was most severe in the substantia nigra, and it was moderate to mild in the ventral part of thalamus,
globus pallidus and striatum. Cytopathologically, in addition to achromatic ballooned neurons, massive tau-positive types
of cytosekeletal abnormalities were observed both in neurons and glia, mainly in the degenerating region. This cytoskeletal
pathology coincided with that reported in corticobasal degeneration (CBD). On Bodian staining, only a few neurofibrillary
tangles were found in the entorhinal pre-alpha layer and substantia nigra. Pick’s bodies and senile plaques could not be found.
This case is thought to represent a type of CBD, but with its cortical lesion focus located in the speech area instead of
the frontoparietal region. A survey of 28 pathologically evaluated cases of CBD revealed two similar cases, both of which
began with progressive aphasia and presented cortical degeneration in the superior temporal gyrus. An overview of CBD cases
clarified the features in another group of cases, in which the cerebral accentuated focus was shifted forward from the central
region, clinically resembling Pick’s disease. The clinical manifestations in CBD seem to be the expression of these diverse
cortical lesions. Primary progressive aphasia may include cases of CBD with involvement of the language center.
Received: 5 February 1996 / Revised, accepted: 13 May 1996 相似文献